InnateDB Protein
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IDBP-2386.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNASE1
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Protein Name
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ribonuclease, RNase A family, 1 (pancreatic)
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Synonyms
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RAC1; RIB1; RNS1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344193
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InnateDB Gene
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IDBG-2384 (RNASE1)
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Protein Structure
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Function |
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. {ECO:0000269PubMed:17350650}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion).
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0090502
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RNA phosphodiester bond hydrolysis, endonucleolytic
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Cellular Component |
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PDB ID |
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InterPro |
IPR001427
Pancreatic ribonuclease
IPR023412
Ribonuclease A-domain
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PFAM |
PF00074
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PRINTS |
PR00794
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PIRSF |
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SMART |
SM00092
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TIGRFAMs |
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Modification |
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SwissProt |
P07998
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PhosphoSite |
PhosphoSite-P07998
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TrEMBL |
W0UV93
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UniProt Splice Variant |
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Entrez Gene |
6035
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UniGene |
Hs.623499
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RefSeq |
NP_937878
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HUGO |
HGNC:10044
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OMIM |
180440
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CCDS |
CCDS9559
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HPRD |
01591
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IMGT |
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EMBL |
AK312100
AL133371
BC005324
BC022882
CH471078
CR450318
D26129
DQ494867
HG328837
S79281
X62946
X79235
|
GenPept |
AAB35096
AAH05324
AAH22882
ABF00144
BAA05124
BAG35036
CAA44718
CAA55817
CAG29314
CDG31913
EAW66437
EAW66438
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