Version 5.4
Homo sapiens Protein: RNASE1
Summary
InnateDB Protein IDBP-2386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE1
Protein Name ribonuclease, RNase A family, 1 (pancreatic)
Synonyms RAC1; RIB1; RNS1;
Species Homo sapiens
Ensembl Protein ENSP00000344193
InnateDB Gene IDBG-2384 (RNASE1)
Protein Structure
UniProt Annotation
Function Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. {ECO:0000269PubMed:17350650}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion).
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004522 pancreatic ribonuclease activity
GO:0005515 protein binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
Biological Process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001427 Pancreatic ribonuclease
IPR023412 Ribonuclease A-domain
PFAM PF00074
PRINTS PR00794
PIRSF
SMART SM00092
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07998
PhosphoSite PhosphoSite-P07998
TrEMBL W0UV93
UniProt Splice Variant
Entrez Gene 6035
UniGene Hs.623499
RefSeq NP_937878
HUGO HGNC:10044
OMIM 180440
CCDS CCDS9559
HPRD 01591
IMGT
EMBL AK312100 AL133371 BC005324 BC022882 CH471078 CR450318 D26129 DQ494867 HG328837 S79281 X62946 X79235
GenPept AAB35096 AAH05324 AAH22882 ABF00144 BAA05124 BAG35036 CAA44718 CAA55817 CAG29314 CDG31913 EAW66437 EAW66438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca