InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PANX2

Summary

InnateDB Protein

IDBP-238733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PANX2

Protein Name

pannexin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379183

InnateDB Gene

IDBG-12842 (PANX2)

Protein Structure

UniProt Annotation

Function

Structural component of the gap junctions and the hemichannels. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00351}. Cell junction, gap junction.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015267	channel activity
GO:0055077	gap junction hemi-channel activity

Biological Process

GO:0002931	response to ischemia
GO:0006811	ion transport
GO:0007268	synaptic transmission
GO:0034214	protein hexamerization
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000990 Innexin

PFAM

PF00876

PRINTS

PR01262

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96RD6

PhosphoSite

PhosphoSite-Q96RD6

TrEMBL

Q6ICA1

UniProt Splice Variant

Entrez Gene

56666

UniGene

Hs.610308

RefSeq

NP_443071

HUGO

HGNC:8600

OMIM

608421

CCDS

CCDS14085

HPRD

09760

IMGT

EMBL

AF398510 AF398511 AK096019 AK299910 AL022328 BC101023 CH471138 CR456467

GenPept

AAI01024 AAK91715 AAK91716 BAG53199 BAH13170 CAG30353 EAW73494