InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL12

Summary

InnateDB Protein

IDBP-238828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL12

Protein Name

chemokine (C-X-C motif) ligand 12

Synonyms

IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000379139

InnateDB Gene

IDBG-71595 (CXCL12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008009	chemokine activity
GO:0008083	growth factor activity
GO:0042379	chemokine receptor binding
GO:0045236	CXCR chemokine receptor binding

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008015	blood circulation
GO:0008064	regulation of actin polymerization or depolymerization
GO:0009615	response to virus
GO:0045785	positive regulation of cell adhesion
GO:0060326	cell chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis
GO:0090280	positive regulation of calcium ion import
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000406	positive regulation of T cell migration