Homo sapiens Gene: CXCL12
InnateDB Gene IDBG-71595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL12
Gene Name chemokine (C-X-C motif) ligand 12
Synonyms IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1;
Species Homo sapiens
Ensembl Gene ENSG00000107562
Encoded Proteins
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
MIR141 directly regulates CXCL12 expression and CXCL12 mediated leukocyte migration during colonic inflammation.
Entrez Gene
Summary This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:44370165-44386493
Strand Reverse strand
Band q11.21
ENST00000374429 ENSP00000363551
ENST00000374426 ENSP00000363548
ENST00000343575 ENSP00000339913
ENST00000395795 ENSP00000379141
ENST00000395794 ENSP00000379140
ENST00000395793 ENSP00000379139
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008009 chemokine activity
GO:0008083 growth factor activity
GO:0042379 chemokine receptor binding
GO:0045236 CXCR chemokine receptor binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001667 ameboidal cell migration
GO:0001764 neuron migration
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007281 germ cell development
GO:0007420 brain development
GO:0008015 blood circulation
GO:0008045 motor neuron axon guidance
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0008354 germ cell migration
GO:0009314 response to radiation
GO:0009408 response to heat
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0022029 telencephalon cell migration
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0031100 organ regeneration
GO:0033603 positive regulation of dopamine secretion
GO:0042098 T cell proliferation
GO:0043434 response to peptide hormone
GO:0045087 innate immune response (InnateDB)
GO:0045666 positive regulation of neuron differentiation
GO:0045785 positive regulation of cell adhesion
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0050930 induction of positive chemotaxis
GO:0051924 regulation of calcium ion transport
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090280 positive regulation of calcium ion import
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Mus musculus
Bos taurus
Gene ID
Gene Order
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signaling by ERBB4 pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
Nuclear signaling by ERBB4 pathway
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Intestinal immune network for IgA production pathway
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
G-protein signaling through tubby proteins [Biocarta view]
Pertussis toxin-insensitive ccr5 signaling in macrophage [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Activation of pkc through g-protein coupled receptors [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
CXCR4-mediated signaling events
HIF-1-alpha transcription factor network
Syndecan-4-mediated signaling events
SwissProt P48061
UniProt Splice Variant
Entrez Gene 6387
UniGene Hs.613659 Hs.617446
RefSeq NM_000609 NM_001033886 NM_001178134 NM_001277990 NM_199168
OMIM 600835
CCDS CCDS44373 CCDS31186 CCDS53527 CCDS60518 CCDS7207
HPRD 02904
EMBL AK292628 AK311814 AL137026 AU120056 AY644456 AY802782 AY874118 BC039893 CH471160 CR450283 DQ345517 DQ345518 DQ345519 DQ345520 L36033 L36034 U16752 U19495
GenPept AAA97434 AAB39332 AAB39333 AAB40516 AAH39893 AAT76437 AAV49999 AAW82036 ABC69270 ABC69271 ABC69272 ABC69273 BAF85317 BAG34757 CAC10202 CAC10203 CAG29279 EAW86619
RNA Seq Atlas 6387