InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCL12

Summary

InnateDB Gene

IDBG-71595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL12

Gene Name

chemokine (C-X-C motif) ligand 12

Synonyms

IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1

Species

Homo sapiens

Ensembl Gene

ENSG00000107562

Encoded Proteins

IDBP-71597

chemokine (C-X-C motif) ligand 12

IDBP-71599

chemokine (C-X-C motif) ligand 12

IDBP-71601

chemokine (C-X-C motif) ligand 12

IDBP-238824

chemokine (C-X-C motif) ligand 12

IDBP-238826

chemokine (C-X-C motif) ligand 12

IDBP-238828

chemokine (C-X-C motif) ligand 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24000293

MIR141 directly regulates CXCL12 expression and CXCL12 mediated leukocyte migration during colonic inflammation.

Entrez Gene

Summary

This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:44370165-44386493

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000374429	ENSP00000363551
ENST00000374426	ENSP00000363548
ENST00000343575	ENSP00000339913
ENST00000395795	ENSP00000379141
ENST00000395794	ENSP00000379140
ENST00000395793	ENSP00000379139
ENST00000496375
ENST00000488591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008009	chemokine activity
GO:0008083	growth factor activity
GO:0042379	chemokine receptor binding
GO:0045236	CXCR chemokine receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001667	ameboidal cell migration
GO:0001764	neuron migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007281	germ cell development
GO:0007420	brain development
GO:0008015	blood circulation
GO:0008045	motor neuron axon guidance
GO:0008064	regulation of actin polymerization or depolymerization
GO:0008284	positive regulation of cell proliferation
GO:0008344	adult locomotory behavior
GO:0008354	germ cell migration
GO:0009314	response to radiation
GO:0009408	response to heat
GO:0009612	response to mechanical stimulus
GO:0009615	response to virus
GO:0022029	telencephalon cell migration
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0031100	organ regeneration
GO:0033603	positive regulation of dopamine secretion
GO:0042098	T cell proliferation
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0045666	positive regulation of neuron differentiation
GO:0045785	positive regulation of cell adhesion
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0050930	induction of positive chemotaxis
GO:0051924	regulation of calcium ion transport
GO:0060326	cell chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis
GO:0090280	positive regulation of calcium ion import
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000406	positive regulation of T cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0070062	extracellular vesicular exosome