InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TYMP

Summary

InnateDB Protein

IDBP-239059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYMP

Protein Name

thymidine phosphorylase

Synonyms

ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP;

Species

Homo sapiens

Ensembl Protein

ENSP00000379037

InnateDB Gene

IDBG-13815 (TYMP)

Protein Structure

UniProt Annotation

Function

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269PubMed:1590793}.Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269PubMed:1590793}.

Subcellular Localization

Disease Associations

Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. {ECO:0000269PubMed:12177387, ECO:0000269PubMed:9924029}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004645	phosphorylase activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0008083	growth factor activity
GO:0009032	thymidine phosphorylase activity
GO:0016154	pyrimidine-nucleoside phosphorylase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016763	transferase activity, transferring pentosyl groups

Biological Process

GO:0000002	mitochondrial genome maintenance
GO:0001525	angiogenesis
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006213	pyrimidine nucleoside metabolic process
GO:0006220	pyrimidine nucleotide metabolic process
GO:0006260	DNA replication
GO:0006935	chemotaxis
GO:0008152	metabolic process
GO:0030154	cell differentiation
GO:0043097	pyrimidine nucleoside salvage
GO:0044281	small molecule metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000053 Pyrimidine-nucleoside phosphorylase
IPR000312 Glycosyl transferase, family 3
IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal
IPR017459 Glycosyl transferase family 3, N-terminal domain
IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic

PFAM

PF00591
PF07831
PF02885

PRINTS

PIRSF

PIRSF000478

SMART

SM00941

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt