Homo sapiens Gene: TYMP
Summary
InnateDB Gene IDBG-13815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYMP
Gene Name thymidine phosphorylase
Synonyms ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP;
Species Homo sapiens
Ensembl Gene ENSG00000025708
Encoded Proteins
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50525752-50530085
Strand Reverse strand
Band q13.33
Transcripts
ENST00000252029 ENSP00000252029
ENST00000395681 ENSP00000379038
ENST00000395680 ENSP00000379037
ENST00000395678 ENSP00000379036
ENST00000425169 ENSP00000395875
ENST00000487577
ENST00000476284
ENST00000487162
ENST00000613148 ENSP00000477950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004645 phosphorylase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0008083 growth factor activity
GO:0009032 thymidine phosphorylase activity
GO:0016154 pyrimidine-nucleoside phosphorylase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016763 transferase activity, transferring pentosyl groups
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0001525 angiogenesis
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006260 DNA replication
GO:0006935 chemotaxis
GO:0008152 metabolic process
GO:0030154 cell differentiation
GO:0043097 pyrimidine nucleoside salvage
GO:0044281 small molecule metabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Pyrimidine catabolism pathway
Pyrimidine salvage reactions pathway
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
Drug metabolism pathway
Bladder cancer pathway
INOH
Purine nucleotides nucleosides metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P19971
TrEMBL C9JGI3 E5KRG5
UniProt Splice Variant
Entrez Gene 1890
UniGene Hs.180903 Hs.685254
RefSeq NM_001113755 NM_001113756 NM_001257988 NM_001257989 NM_001953
HUGO HGNC:3148
OMIM 131222
CCDS CCDS14096 CCDS58811
HPRD
IMGT
EMBL AK225269 BC018160 BC052211 CH471138 HQ205666 HQ205667 HQ205668 HQ205669 HQ205670 HQ205671 HQ205672 HQ205673 HQ205674 HQ205675 HQ205676 HQ205677 HQ205678 HQ205679 HQ205680 HQ205681 HQ205682 HQ205683 HQ205684 HQ205685 HQ205686 HQ205687 HQ205688 HQ205689 HQ205690 HQ205691 HQ205692 HQ205693 HQ205694 HQ205695 HQ205696 HQ205697 HQ205698 HQ205699 HQ205700 HQ205701 HQ205702 HQ205703 HQ205704 HQ205705 M63193 U62317
GenPept AAA60043 AAB03344 AAH18160 AAH52211 ADP91494 ADP91495 ADP91496 ADP91497 ADP91498 ADP91499 ADP91500 ADP91501 ADP91502 ADP91503 ADP91504 ADP91505 ADP91506 ADP91507 ADP91508 ADP91509 ADP91510 ADP91511 ADP91512 ADP91513 ADP91514 ADP91515 ADP91516 ADP91517 ADP91518 ADP91519 ADP91520 ADP91521 ADP91522 ADP91523 ADP91524 ADP91525 ADP91526 ADP91527 ADP91528 ADP91529 ADP91530 ADP91531 ADP91532 ADP91533 EAW73560 EAW73561 EAW73562 EAW73563 EAW73564
RNA Seq Atlas 1890