InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TYMP

Summary

InnateDB Gene

IDBG-13815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYMP

Gene Name

thymidine phosphorylase

Synonyms

ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP

Species

Homo sapiens

Ensembl Gene

ENSG00000025708

Encoded Proteins

IDBP-13817

thymidine phosphorylase

IDBP-239057

thymidine phosphorylase

IDBP-239059

thymidine phosphorylase

IDBP-239061

thymidine phosphorylase

IDBP-381398

thymidine phosphorylase

IDBP-807364

thymidine phosphorylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:50525752-50530085

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000252029	ENSP00000252029
ENST00000395681	ENSP00000379038
ENST00000395680	ENSP00000379037
ENST00000395678	ENSP00000379036
ENST00000425169	ENSP00000395875
ENST00000487577
ENST00000476284
ENST00000487162
ENST00000613148	ENSP00000477950

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004645	phosphorylase activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0008083	growth factor activity
GO:0009032	thymidine phosphorylase activity
GO:0016154	pyrimidine-nucleoside phosphorylase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016763	transferase activity, transferring pentosyl groups

Biological Process

GO:0000002	mitochondrial genome maintenance
GO:0001525	angiogenesis
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006213	pyrimidine nucleoside metabolic process
GO:0006220	pyrimidine nucleotide metabolic process
GO:0006260	DNA replication
GO:0006935	chemotaxis
GO:0008152	metabolic process
GO:0030154	cell differentiation
GO:0043097	pyrimidine nucleoside salvage
GO:0044281	small molecule metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000022615

View Gene Order

Pathways

NETPATH

REACTOME

REACT_655

Pyrimidine salvage reactions pathway

REACT_1023

Pyrimidine catabolism pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_957

Pyrimidine metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa05219

Bladder cancer pathway

hsa00983

Drug metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.180903 Hs.685254

RefSeq

NM_001113755 NM_001113756 NM_001257988 NM_001257989 NM_001953

HUGO

OMIM

CCDS

CCDS14096 CCDS58811

HPRD

08833

IMGT

EMBL

GenPept

RNA Seq Atlas