InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKG2

Summary

InnateDB Protein

IDBP-239277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKG2

Protein Name

protein kinase, cGMP-dependent, type II

Synonyms

cGK2; cGKII; PRKGR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000378945

InnateDB Gene

IDBG-26622 (PRKG2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:8636133}; Lipid-anchor {ECO:0000269PubMed:8636133}.

Disease Associations

Tissue Specificity

Highly concentrated in brain, lung and intestinal mucosa.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004692	cGMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030553	cGMP binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity

Cellular Component

GO:0005829	cytosol
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR002374 cGMP-dependent kinase
IPR011009 Protein kinase-like domain
IPR016232 cGMP-dependent protein kinase
IPR018490 Cyclic nucleotide-binding-like
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00027
PF00069
PF07714

PRINTS

PR00109
PR00103
PR00104

PIRSF

PIRSF000559

SMART

SM00100
SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References