Homo sapiens Gene: PRKG2
Summary
InnateDB Gene IDBG-26622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKG2
Gene Name protein kinase, cGMP-dependent, type II
Synonyms cGK2; cGKII; PRKGR2;
Species Homo sapiens
Ensembl Gene ENSG00000138669
Encoded Proteins
protein kinase, cGMP-dependent, type II
protein kinase, cGMP-dependent, type II
protein kinase, cGMP-dependent, type II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:81087370-81215117
Strand Reverse strand
Band q21.21
Transcripts
ENST00000264399 ENSP00000264399
ENST00000395578 ENSP00000378945
ENST00000456882
ENST00000509169
ENST00000509474
ENST00000545647 ENSP00000439967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030553 cGMP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0007623 circadian rhythm
GO:0032922 circadian regulation of gene expression
GO:0036289 peptidyl-serine autophosphorylation
GO:0044281 small molecule metabolic process
GO:0046209 nitric oxide metabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0072661 protein targeting to plasma membrane
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
eNOS activation and regulation pathway
Signaling by Wnt pathway
cGMP effects pathway
Metabolism of nitric oxide pathway
Signal Transduction pathway
Platelet homeostasis pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Metabolism pathway
Hemostasis pathway
Nitric oxide stimulates guanylate cyclase pathway
KEGG
Gap junction pathway
Long-term depression pathway
Olfactory transduction pathway
Salivary secretion pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Actions of nitric oxide in the heart [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.570833 Hs.739943
RefSeq NM_001282480 NM_001282481 NM_001282482 NM_001282483 NM_001282485 NM_006259 XM_005263126 XM_006714266
HUGO
OMIM
CCDS CCDS3589 CCDS75150
HPRD 09034
IMGT
EMBL
GenPept
RNA Seq Atlas