Version 5.4
Homo sapiens Gene: PRKG2
Summary
InnateDB Gene IDBG-26622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKG2
Gene Name protein kinase, cGMP-dependent, type II
Synonyms cGK2; cGKII; PRKGR2
Species Homo sapiens
Ensembl Gene ENSG00000138669
Encoded Proteins
IDBP-26624
protein kinase, cGMP-dependent, type II
IDBP-239277
protein kinase, cGMP-dependent, type II
IDBP-593267
protein kinase, cGMP-dependent, type II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:81087370-81215117
Strand Reverse strand
Band q21.21
Transcripts
ENST00000264399 ENSP00000264399
ENST00000395578 ENSP00000378945
ENST00000456882
ENST00000509169
ENST00000509474
ENST00000545647 ENSP00000439967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030553 cGMP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0007623 circadian rhythm
GO:0032922 circadian regulation of gene expression
GO:0036289 peptidyl-serine autophosphorylation
GO:0044281 small molecule metabolic process
GO:0046209 nitric oxide metabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0072661 protein targeting to plasma membrane
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029334
View Gene Order
ENSBTAG00000002978
Not yet available
Pathways
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_12389
eNOS activation and regulation pathway
REACT_11045
Signaling by Wnt pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111102
Signal Transduction pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04540
Gap junction pathway
hsa04740
Olfactory transduction pathway
hsa04730
Long-term depression pathway
hsa04970
Salivary secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt Q13237
TrEMBL B7ZA25
UniProt Splice Variant
Entrez Gene 5593
UniGene Hs.570833 Hs.739943
RefSeq NM_001282485 NM_006259 XM_005263126 XM_006714266 NM_001282480 NM_001282481 NM_001282482 NM_001282483
HUGO HGNC:9416
OMIM 601591
CCDS CCDS3589 CCDS75150
HPRD 09034
IMGT
EMBL AC098819 AC139722 AK297673 AK316140 D70899 X94612 Y16106 Y16107 Y16108 Y16109 Y16110 Y16111 Y16112 Y16113 Y16114 Y16115 Y16116 Y16117 Y16118 Y16119 Y16120 Y16121 Y16122 Y16123
GenPept BAA18934 BAG60035 BAH14511 CAA64318 CAA76073
RNA Seq Atlas 5593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca