Version 5.4
Homo sapiens Protein: SPECC1
Summary
InnateDB Protein IDBP-239376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPECC1
Protein Name sperm antigen with calponin homology and coiled-coil domains 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378898
InnateDB Gene IDBG-35228 (SPECC1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus {ECO:0000269PubMed:15602574}.
Disease Associations Note=A chromosomal aberration involving CYTSB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with PDGFRB.
Tissue Specificity Highly expressed in testis. Barely detectable in other tissues. Also highly expressed in some cancer cell lines. {ECO:0000269PubMed:15602574}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
PFAM PF00307
PF11971
PRINTS
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5M775
PhosphoSite PhosphoSite-Q5M775
TrEMBL J3QSD6
UniProt Splice Variant
Entrez Gene 92521
UniGene Hs.740153
RefSeq NP_001230368
HUGO HGNC:30615
OMIM 608793
CCDS CCDS32590
HPRD 12301
IMGT
EMBL AB041533 AC004702 AC005730 AC007963 AC008088 AK295093 AK298601 AY816326 AY816327 AY816328 AY816329 BC021123 BC033618 BC050058 BK005598 CH471212
GenPept AAH21123 AAH33618 AAH50058 AAW29999 AAW30000 AAW30001 AAW30002 BAB16440 BAG58132 BAG60786 DAA05629 DAA05630 DAA05631 DAA05632 EAW50914 EAW50917

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca