InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KTN1

Summary

InnateDB Protein

IDBP-239679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KTN1

Protein Name

kinectin 1 (kinesin receptor)

Synonyms

CG1; KNT; MU-RMS-40.19;

Species

Homo sapiens

Ensembl Protein

ENSP00000378720

InnateDB Gene

IDBG-7393 (KTN1)

Protein Structure

UniProt Annotation

Function

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane protein anchored to the endoplasmic reticulum.

Disease Associations

Tissue Specificity

High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019894	kinesin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007018	microtubule-based movement
GO:0015031	protein transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane