InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP24

Summary

InnateDB Protein

IDBP-240073.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP24

Protein Name

Rho GTPase activating protein 24

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378611

InnateDB Gene

IDBG-28243 (ARHGAP24)

Protein Structure

UniProt Annotation

Function

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269PubMed:15302923, ECO:0000269PubMed:15611138, ECO:0000269PubMed:16862148}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.

Disease Associations

Tissue Specificity

Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells. {ECO:0000269PubMed:15302923, ECO:0000269PubMed:15611138, ECO:0000269PubMed:16862148}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0001525	angiogenesis
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0030154	cell differentiation
GO:0032863	activation of Rac GTPase activity
GO:0035021	negative regulation of Rac protein signal transduction
GO:0035313	wound healing, spreading of epidermal cells
GO:0051056	regulation of small GTPase mediated signal transduction
GO:1900028	negative regulation of ruffle assembly