Version 5.4
Homo sapiens Gene: ARHGAP24
Summary
InnateDB Gene IDBG-28243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP24
Gene Name Rho GTPase activating protein 24
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138639
Encoded Proteins
IDBP-28249
Rho GTPase activating protein 24
IDBP-240073
Rho GTPase activating protein 24
IDBP-240075
Rho GTPase activating protein 24
IDBP-480270
Rho GTPase activating protein 24
IDBP-473599
Rho GTPase activating protein 24
IDBP-480008
Rho GTPase activating protein 24
IDBP-484672
Rho GTPase activating protein 24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:85475114-86002670
Strand Forward strand
Band q21.23
Transcripts
ENST00000264343 ENSP00000264343
ENST00000395184 ENSP00000378611
ENST00000395183 ENSP00000378610
ENST00000503995 ENSP00000423206
ENST00000506421
ENST00000505856
ENST00000509709
ENST00000512201 ENSP00000426105
ENST00000509300 ENSP00000424256
ENST00000514229 ENSP00000425589
ENST00000502537
ENST00000503917
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0030154 cell differentiation
GO:0032863 activation of Rac GTPase activity
GO:0035021 negative regulation of Rac protein signal transduction
GO:0035313 wound healing, spreading of epidermal cells
GO:0051056 regulation of small GTPase mediated signal transduction
GO:1900028 negative regulation of ruffle assembly
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057315
View Gene Order
ENSBTAG00000003959
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444229 Hs.630310 Hs.672231
RefSeq NM_001025616 NM_001042669 NM_001287805 NM_031305 XM_005263263
HUGO
OMIM
CCDS CCDS34025 CCDS3611 CCDS43246
HPRD 09804
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca