InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPP1

Summary

InnateDB Protein

IDBP-240243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPP1

Protein Name

secreted phosphoprotein 1

Synonyms

BNSP; BSPI; ETA-1; OPN;

Species

Homo sapiens

Ensembl Protein

ENSP00000378517

InnateDB Gene

IDBG-29322 (SPP1)

Protein Structure

UniProt Annotation

Function

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Bone. Found in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007566	embryo implantation
GO:0010033	response to organic substance
GO:0010811	positive regulation of cell-substrate adhesion
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0031214	biomineral tissue development
GO:0033280	response to vitamin D
GO:0045087	innate immune response (InnateDB)
GO:0045780	positive regulation of bone resorption
GO:0046697	decidualization
GO:0048545	response to steroid hormone
GO:0048685	negative regulation of collateral sprouting of intact axon in response to injury

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031988	membrane-bounded vesicle
GO:0042995	cell projection
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome