Homo sapiens Gene: SPP1
Summary
InnateDB Gene IDBG-29322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPP1
Gene Name secreted phosphoprotein 1
Synonyms BNSP; BSPI; ETA-1; OPN;
Species Homo sapiens
Ensembl Gene ENSG00000118785
Encoded Proteins
secreted phosphoprotein 1
secreted phosphoprotein 1
secreted phosphoprotein 1
secreted phosphoprotein 1
secreted phosphoprotein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SPP1 exist in secreted and intracellular form; intracellular SPP1, or iSPP1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Spp1 exist in secreted and intracellular form; intracellular Spp1, or iSpp1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.
Entrez Gene
Summary The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:87975650-87983426
Strand Forward strand
Band q22.1
Transcripts
ENST00000237623 ENSP00000237623
ENST00000360804 ENSP00000354042
ENST00000395080 ENSP00000378517
ENST00000504310
ENST00000513981
ENST00000509334
ENST00000508233 ENSP00000422973
ENST00000509659
ENST00000508002
ENST00000505146
ENST00000614857 ENSP00000477824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007566 embryo implantation
GO:0010033 response to organic substance
GO:0010811 positive regulation of cell-substrate adhesion
GO:0022617 extracellular matrix disassembly
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0031214 biomineral tissue development
GO:0033280 response to vitamin D
GO:0045087 innate immune response (InnateDB)
GO:0045780 positive regulation of bone resorption
GO:0046697 decidualization
GO:0048545 response to steroid hormone
GO:0048685 negative regulation of collateral sprouting of intact axon in response to injury
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0031988 membrane-bounded vesicle
GO:0042995 cell projection
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Signal Transduction pathway
Integrin cell surface interactions pathway
Signaling by PDGF pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Toll-like receptor signaling pathway pathway
INOH
PID BIOCARTA
Regulators of bone mineralization [Biocarta view]
PID NCI
Beta1 integrin cell surface interactions
Integrins in angiogenesis
Direct p53 effectors
Alpha9 beta1 integrin signaling events
FGF signaling pathway
Alpha4 beta1 integrin signaling events
Beta3 integrin cell surface interactions
Osteopontin-mediated events
Cross-References
SwissProt P10451
TrEMBL A0A024RDE2 A0A024RDE6 A0A024RDJ0 D6R9C5 F2YBS4 F2YBS5 F2YQ21 Q3LGB0
UniProt Splice Variant
Entrez Gene 6696
UniGene Hs.313 Hs.705703
RefSeq NM_000582 NM_001040058 NM_001040060 NM_001251829 NM_001251830
HUGO HGNC:11255
OMIM 166490
CCDS CCDS34027 CCDS3626 CCDS43250
HPRD
IMGT
EMBL AB209987 AC131944 AF052124 AK075463 AK290090 AK290104 AK296035 AK315461 BC007016 BC017387 BC022844 BC093033 CH471057 D14813 D28759 D28760 D28761 DQ839491 DQ846871 HQ874460 HQ874461 J04765 JF412666 JF412667 M83248 U20758 X13694
GenPept AAA17675 AAA59974 AAA86886 AAC28619 AAH07016 AAH17387 AAH22844 AAH93033 AAY41035 ABI63352 ABI63358 AEA49027 AEA49028 AEA49030 AEA49031 BAA03554 BAA05949 BAA05950 BAA05951 BAC11635 BAE45628 BAF82779 BAF82793 BAG37848 BAG58801 CAA31984 EAX06004 EAX06005 EAX06006 EAX06007 EAX06008 EAX06009 EAX06010
RNA Seq Atlas 6696