InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM23

Summary

InnateDB Protein

IDBP-24051.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM23

Protein Name

tripartite motif containing 23

Synonyms

ARD1; ARFD1; RNF46;

Species

Homo sapiens

Ensembl Protein

ENSP00000274327

InnateDB Gene

IDBG-24045 (TRIM23)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. {ECO:0000269PubMed:15684077}.

Subcellular Localization

Endomembrane system {ECO:0000269PubMed:9671726}. Golgi apparatus membrane {ECO:0000269PubMed:9671726}. Lysosome membrane {ECO:0000269PubMed:9671726}. Note=Membrane-associated with the Golgi complex and lysosomal structures.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.

Experimentally validated
Total	157 [view]
Protein-Protein	155 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008047	enzyme activator activity
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019001	guanyl nucleotide binding
GO:0019003	GDP binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0043085	positive regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR001841 Zinc finger, RING-type
IPR003579 Small GTPase superfamily, Rab type
IPR003649 B-box, C-terminal
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR007087 Zinc finger, C2H2
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM