InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FLOT2

Summary

InnateDB Protein

IDBP-240626.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLOT2

Protein Name

flotillin 2

Synonyms

ECS-1; ECS1; ESA; ESA1; M17S1;

Species

Homo sapiens

Ensembl Protein

ENSP00000378368

InnateDB Gene

IDBG-37810 (FLOT2)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20682791}; Peripheral membrane protein {ECO:0000269PubMed:20682791}. Membrane, caveola {ECO:0000269PubMed:20682791}; Peripheral membrane protein {ECO:0000269PubMed:20682791}. Endosome {ECO:0000269PubMed:20682791}. Note=Membrane-associated protein of caveolae.

Disease Associations

Tissue Specificity

In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	51 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0007155	cell adhesion
GO:0008544	epidermis development
GO:0010629	negative regulation of gene expression
GO:0050821	protein stabilization
GO:0090002	establishment of protein localization to plasma membrane
GO:1902992	negative regulation of amyloid precursor protein catabolic process

Cellular Component

GO:0002080	acrosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0016600	flotillin complex
GO:0030139	endocytic vesicle
GO:0031982	vesicle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome