InnateDB Protein
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IDBP-240875.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD36
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Protein Name
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CD36 molecule (thrombospondin receptor)
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Synonyms
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BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378268
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InnateDB Gene
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IDBG-24023 (CD36)
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Protein Structure
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Function |
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. {ECO:0000269PubMed:10890433, ECO:0000269PubMed:12506336}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. {ECO:0000269PubMed:11950861, ECO:0000269PubMed:7533783}. Note=The disease is caused by mutations affecting the gene represented in this entry.Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269PubMed:15282206}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001954
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positive regulation of cell-matrix adhesion
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GO:0002224
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toll-like receptor signaling pathway
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GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0002576
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platelet degranulation
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GO:0002755
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MyD88-dependent toll-like receptor signaling pathway
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GO:0006629
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lipid metabolic process
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GO:0006898
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receptor-mediated endocytosis
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GO:0007155
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cell adhesion
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GO:0007263
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nitric oxide mediated signal transduction
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GO:0007596
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blood coagulation
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GO:0010744
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positive regulation of macrophage derived foam cell differentiation
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GO:0015911
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plasma membrane long-chain fatty acid transport
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GO:0019915
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lipid storage
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GO:0019934
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cGMP-mediated signaling
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GO:0030168
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platelet activation
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GO:0030301
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cholesterol transport
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GO:0034134
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toll-like receptor 2 signaling pathway
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GO:0034142
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toll-like receptor 4 signaling pathway
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GO:0034381
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plasma lipoprotein particle clearance
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GO:0034383
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low-density lipoprotein particle clearance
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GO:0038123
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toll-like receptor TLR1:TLR2 signaling pathway
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GO:0038124
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toll-like receptor TLR6:TLR2 signaling pathway
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0042953
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lipoprotein transport
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0044539
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long-chain fatty acid import
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GO:0045087
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innate immune response (InnateDB)
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Cellular Component |
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PDB ID |
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InterPro |
IPR002159
CD36 antigen
IPR005428
Adhesion molecule CD36
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PFAM |
PF01130
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PRINTS |
PR01609
PR01610
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P16671
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PhosphoSite |
PhosphoSite-P16671
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TrEMBL |
V5M404
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UniProt Splice Variant |
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Entrez Gene |
948
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UniGene |
Hs.736825
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RefSeq |
NP_000063
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HUGO |
HGNC:1663
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OMIM |
173510
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CCDS |
CCDS34673
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HPRD |
01430
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IMGT |
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EMBL |
AC004862
AC073182
AC073850
AC092108
AC124834
AF300625
AF300626
AF300627
AF300628
AF300629
AF300632
AF300633
AF300634
AF300635
AF300636
AF300637
AF300639
AF300640
AK312920
AY095373
BC008406
CH236949
CH471091
KF539919
L06850
M24795
M98398
M98399
S67044
S67532
Z22924
Z32754
Z32755
Z32756
Z32757
Z32758
Z32759
Z32760
Z32761
Z32762
Z32763
Z32764
Z32770
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GenPept |
AAA16068
AAA35534
AAA58412
AAA58413
AAB28992
AAD13993
AAG60624
AAG60625
AAG60626
AAG60627
AAG60628
AAG60631
AAG60632
AAG60633
AAG60634
AAG60635
AAG60636
AAG60638
AAG60639
AAH08406
AAM14636
AHA62517
BAG35765
CAA80504
CAA83662
EAL24191
EAW76996
EAW76997
EAW76998
EAW76999
EAW77000
EAW77001
EAW77002
EAW77003
EAW77004
EAW77005
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