InnateDB Protein
|
IDBP-241195.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
STEAP2
|
Protein Name
|
STEAP family member 2, metalloreductase
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000378125
|
InnateDB Gene
|
IDBG-25663 (STEAP2)
|
Protein Structure
|
|
Function |
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269PubMed:12429817}; Multi-pass membrane protein {ECO:0000269PubMed:12429817}.
|
Disease Associations |
|
Tissue Specificity |
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary. {ECO:0000269PubMed:12095985, ECO:0000269PubMed:12429817, ECO:0000269PubMed:16609065}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR013130
Ferric reductase transmembrane component-like domain
IPR028939
Pyrroline-5-carboxylate reductase, catalytic, N-terminal
|
PFAM |
PF01794
PF03807
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8NFT2
|
PhosphoSite |
PhosphoSite-Q8NFT2
|
TrEMBL |
Q6YPB2
|
UniProt Splice Variant |
|
Entrez Gene |
261729
|
UniGene |
Hs.633629
|
RefSeq |
NP_001035756
|
HUGO |
HGNC:17885
|
OMIM |
605094
|
CCDS |
CCDS43612
|
HPRD |
05481
|
IMGT |
|
EMBL |
AC002064
AC004969
AF455138
AF526382
AY008443
AY008444
AY008445
AY358267
CH236949
CH471091
|
GenPept |
AAG32147
AAG32148
AAG32149
AAN04080
AAQ08976
AAQ88634
EAL24165
EAW76889
EAW76890
EAW76891
EAW76892
EAW76893
EAW76894
|
|
|