Version 5.4
Homo sapiens Gene: STEAP2
Summary
InnateDB Gene IDBG-25663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STEAP2
Gene Name STEAP family member 2, metalloreductase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157214
Encoded Proteins
IDBP-25665
STEAP family member 2, metalloreductase
IDBP-241193
STEAP family member 2, metalloreductase
IDBP-241195
STEAP family member 2, metalloreductase
IDBP-241197
STEAP family member 2, metalloreductase
IDBP-241201
STEAP family member 2, metalloreductase
IDBP-241203
STEAP family member 2, metalloreductase
IDBP-295478
STEAP family member 2, metalloreductase
IDBP-381245
STEAP family member 2, metalloreductase
IDBP-381254
STEAP family member 2, metalloreductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:90167590-90238137
Strand Forward strand
Band q21.13
Transcripts
ENST00000287908 ENSP00000287908
ENST00000394632 ENSP00000378128
ENST00000394629 ENSP00000378125
ENST00000394626 ENSP00000378123
ENST00000394622 ENSP00000378120
ENST00000394621 ENSP00000378119
ENST00000402625 ENSP00000384191
ENST00000428074 ENSP00000401783
ENST00000426158 ENSP00000415931
ENST00000482369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008823 cupric reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
Biological Process
GO:0006811 ion transport
GO:0006893 Golgi to plasma membrane transport
GO:0006897 endocytosis
GO:0009725 response to hormone
GO:0015677 copper ion import
GO:0045055 regulated secretory pathway
GO:0055072 iron ion homeostasis
GO:0055114 oxidation-reduction process
GO:0097461 ferric iron import into cell
Cellular Component
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0030173 integral component of Golgi membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000015653
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000003506
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25060
Iron uptake and transport pathway
REACT_25283
Transferrin endocytosis and recycling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.489051 Hs.622277 Hs.633629
RefSeq NM_001040665 NM_001040666 NM_001244944 NM_001244945 NM_001244946 NM_152999 XM_006715921 XM_006715922
HUGO
OMIM
CCDS CCDS43612 CCDS5615 CCDS59064
HPRD 05481
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca