InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STEAP2

Summary

InnateDB Protein

IDBP-241203.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STEAP2

Protein Name

STEAP family member 2, metalloreductase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378119

InnateDB Gene

IDBG-25663 (STEAP2)

Protein Structure

UniProt Annotation

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}.

Subcellular Localization

Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269PubMed:12429817}; Multi-pass membrane protein {ECO:0000269PubMed:12429817}.

Disease Associations

Tissue Specificity

Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary. {ECO:0000269PubMed:12095985, ECO:0000269PubMed:12429817, ECO:0000269PubMed:16609065}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008823	cupric reductase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006811	ion transport
GO:0006893	Golgi to plasma membrane transport
GO:0006897	endocytosis
GO:0009725	response to hormone
GO:0015677	copper ion import
GO:0045055	regulated secretory pathway
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0030173	integral component of Golgi membrane
GO:0043231	intracellular membrane-bounded organelle