InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCLK1

Summary

InnateDB Protein

IDBP-24124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCLK1

Protein Name

doublecortin-like kinase 1

Synonyms

CL1; CLICK1; DCAMKL1; DCDC3A; DCLK;

Species

Homo sapiens

Ensembl Protein

ENSP00000353846

InnateDB Gene

IDBG-24120 (DCLK1)

Protein Structure

UniProt Annotation

Function

Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Subcellular Localization

Disease Associations

Tissue Specificity

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. {ECO:0000269PubMed:10051403}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0007417	central nervous system development
GO:0009615	response to virus
GO:0016197	endosomal transport
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003533 Doublecortin domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF03607

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00537
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt