InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF14

Summary

InnateDB Protein

IDBP-241415.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF14

Protein Name

ring finger protein 14

Synonyms

ARA54; HFB30; TRIAD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000378028

InnateDB Gene

IDBG-51094 (RNF14)

Protein Structure

UniProt Annotation

Function

Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription. {ECO:0000269PubMed:19345326}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9853615}. Nucleus {ECO:0000269PubMed:9853615}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019787	small conjugating protein ligase activity
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0016567	protein ubiquitination
GO:0030521	androgen receptor signaling pathway
GO:0032355	response to estradiol
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway