Homo sapiens Gene: RNF14
Summary
InnateDB Gene IDBG-51094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF14
Gene Name ring finger protein 14
Synonyms ARA54; HFB30; TRIAD2;
Species Homo sapiens
Ensembl Gene ENSG00000013561
Encoded Proteins
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
ring finger protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141958328-141990291
Strand Forward strand
Band q31.3
Transcripts
ENST00000356143 ENSP00000348462
ENST00000347642 ENSP00000324956
ENST00000394520 ENSP00000378028
ENST00000394519 ENSP00000378027
ENST00000394514 ENSP00000378022
ENST00000511961 ENSP00000423420
ENST00000506822 ENSP00000423273
ENST00000513019 ENSP00000421780
ENST00000514620
ENST00000502341
ENST00000506938 ENSP00000420837
ENST00000512565 ENSP00000426832
ENST00000515613 ENSP00000422650
ENST00000507163 ENSP00000422527
ENST00000506004 ENSP00000425361
ENST00000507291 ENSP00000423294
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019787 small conjugating protein ligase activity
GO:0050681 androgen receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0016567 protein ubiquitination
GO:0030521 androgen receptor signaling pathway
GO:0032355 response to estradiol
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060765 regulation of androgen receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6R988 D6R996 D6RAS4
UniProt Splice Variant
Entrez Gene 9604
UniGene Hs.483616 Hs.508993
RefSeq NM_001201365 NM_004290 NM_183398 NM_183399 NM_183400 NM_183401 XM_005268538 XM_005268539 XM_005268540 XM_005268541
HUGO HGNC:10058
OMIM 605675
CCDS CCDS4270 CCDS4271
HPRD 05745
IMGT
EMBL AC005740
GenPept
RNA Seq Atlas 9604