InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCERG1

Summary

InnateDB Protein

IDBP-241612.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCERG1

Protein Name

transcription elongation regulator 1

Synonyms

CA150; TAF2S; Urn1;

Species

Homo sapiens

Ensembl Protein

ENSP00000377943

InnateDB Gene

IDBG-52069 (TCERG1)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269PubMed:11604498, ECO:0000269PubMed:9315662}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10908677, ECO:0000269PubMed:15485897, ECO:0000269PubMed:9315662}.

Disease Associations

Tissue Specificity

Detected in brain neurons. {ECO:0000269PubMed:11172033}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	101 [view]
Protein-Protein	97 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding