InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRC1

Summary

InnateDB Protein

IDBP-241964.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRC1

Protein Name

protein regulator of cytokinesis 1

Synonyms

ASE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000377793

InnateDB Gene

IDBG-30703 (PRC1)

Protein Structure

UniProt Annotation

Function

Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. {ECO:0000269PubMed:12082078, ECO:0000269PubMed:15297875, ECO:0000269PubMed:15625105, ECO:0000269PubMed:16431929, ECO:0000269PubMed:19468300, ECO:0000269PubMed:20691902, ECO:0000269PubMed:9885575}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	27 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding

Biological Process

GO:0000022	mitotic spindle elongation
GO:0000226	microtubule cytoskeleton organization
GO:0000910	cytokinesis

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton