InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRB7

Summary

InnateDB Protein

IDBP-242039.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRB7

Protein Name

growth factor receptor-bound protein 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377759

InnateDB Gene

IDBG-46213 (GRB7)

Protein Structure

UniProt Annotation

Function

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule {ECO:0000250}. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	73 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding

Biological Process

GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007596	blood coagulation
GO:0009967	positive regulation of signal transduction
GO:0017148	negative regulation of translation
GO:0030335	positive regulation of cell migration
GO:0034063	stress granule assembly
GO:0050900	leukocyte migration

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0010494	cytoplasmic stress granule
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
IPR015042 BPS (Between PH and SH2) domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00017
PF14633
PF00169
PF08947

PRINTS

PR00401

PIRSF

SMART

SM00314
SM00252
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt