Version 5.4
Homo sapiens Gene: GRB7
Summary
InnateDB Gene IDBG-46213.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB7
Gene Name growth factor receptor-bound protein 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141738
Encoded Proteins
IDBP-46215
growth factor receptor-bound protein 7
IDBP-242037
growth factor receptor-bound protein 7
IDBP-242039
growth factor receptor-bound protein 7
IDBP-242041
growth factor receptor-bound protein 7
IDBP-377283
growth factor receptor-bound protein 7
IDBP-760842
IDBP-760388
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39737927-39747291
Strand Forward strand
Band q12
Transcripts
ENST00000309156 ENSP00000310771
ENST00000394211 ENSP00000377761
ENST00000394209 ENSP00000377759
ENST00000394204 ENSP00000377754
ENST00000445327 ENSP00000403459
ENST00000485182
ENST00000461756
ENST00000473071
ENST00000578702
ENST00000584853
ENST00000577695 ENSP00000463416
ENST00000584819
ENST00000584053
ENST00000583813 ENSP00000463126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007596 blood coagulation
GO:0009967 positive regulation of signal transduction
GO:0017148 negative regulation of translation
GO:0030335 positive regulation of cell migration
GO:0034063 stress granule assembly
GO:0050900 leukocyte migration
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0010494 cytoplasmic stress granule
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019312
View Gene Order
ENSBTAG00000017366
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_115896
GRB7 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_111102
Signal Transduction pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
ephbfwdpathway
EPHB forward signaling
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
ret_pathway
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.737212 Hs.86859
RefSeq NM_001030002 NM_001242442 NM_001242443 NM_005310 XM_006721844
HUGO
OMIM
CCDS CCDS11345 CCDS56028
HPRD 03311
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca