InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLC2

Summary

InnateDB Protein

IDBP-242345.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLC2

Protein Name

kinesin light chain 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377630

InnateDB Gene

IDBG-58526 (KLC2)

Protein Structure

UniProt Annotation

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0019894	kinesin binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0016938	kinesin I complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR002151 Kinesin light chain
IPR013026 Tetratricopeptide repeat-containing domain
IPR015390 Rabaptin, GTPase-Rab5 binding domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF09311
PF13174
PF13176
PF13181

PRINTS

PR00381

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt