InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMMR

Summary

InnateDB Protein

IDBP-242635.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMMR

Protein Name

hyaluronan-mediated motility receptor (RHAMM)

Synonyms

CD168; IHABP; RHAMM;

Species

Homo sapiens

Ensembl Protein

ENSP00000377492

InnateDB Gene

IDBG-56581 (HMMR)

Protein Structure

UniProt Annotation

Function

Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity.

Subcellular Localization

Cell surface. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in breast cancer cell lines and in normal breast tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	29 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005540	hyaluronic acid binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0044281	small molecule metabolic process