Homo sapiens Gene: HMMR
Summary
InnateDB Gene IDBG-56581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMMR
Gene Name hyaluronan-mediated motility receptor (RHAMM)
Synonyms CD168; IHABP; RHAMM;
Species Homo sapiens
Ensembl Gene ENSG00000072571
Encoded Proteins
hyaluronan-mediated motility receptor (RHAMM)
hyaluronan-mediated motility receptor (RHAMM)
hyaluronan-mediated motility receptor (RHAMM)
hyaluronan-mediated motility receptor (RHAMM)
hyaluronan-mediated motility receptor (RHAMM)
hyaluronan-mediated motility receptor (RHAMM)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:163460203-163491945
Strand Forward strand
Band q34
Transcripts
ENST00000358715 ENSP00000351554
ENST00000353866 ENSP00000185942
ENST00000393915 ENSP00000377492
ENST00000432118 ENSP00000402673
ENST00000520345 ENSP00000428481
ENST00000522094 ENSP00000428406
ENST00000521108
ENST00000517936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 29 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005540 hyaluronic acid binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030214 hyaluronan catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Hyaluronan uptake and degradation pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
Hyaluronan metabolism pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
ECM-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O75330
TrEMBL B9UCQ3 E5RI30 E5RIH2
UniProt Splice Variant
Entrez Gene 3161
UniGene Hs.740467
RefSeq NM_012484 NM_001142556 NM_001142557 NM_012485
HUGO HGNC:5012
OMIM 600936
CCDS CCDS4362 CCDS4363 CCDS47334 CCDS47335
HPRD 02963
IMGT
EMBL AC112205 AF032862 AK290577 AK303616 BC108904 CH471062 EU526024 U29343
GenPept AAC32548 AAC52049 AAI08905 ACD35245 BAF83266 BAG64626 EAW61522 EAW61523 EAW61524 EAW61525
RNA Seq Atlas 3161