InnateDB Protein
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IDBP-243083.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL18BP
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Protein Name
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interleukin 18 binding protein
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Synonyms
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IL18BPa;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377310
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InnateDB Gene
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IDBG-62960 (IL18BP)
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Protein Structure
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Function |
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. {ECO:0000269PubMed:10023777, ECO:0000269PubMed:10655506}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in heart, lung, placenta and spleen. {ECO:0000269PubMed:10023777, ECO:0000269PubMed:10094485}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0042088
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T-helper 1 type immune response
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GO:1900116
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extracellular negative regulation of signal transduction
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95998
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PhosphoSite |
PhosphoSite-O95998
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TrEMBL |
A0A024R5M7
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UniProt Splice Variant |
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Entrez Gene |
10068
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UniGene |
Hs.591967
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RefSeq |
NP_001138527
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HUGO |
HGNC:5987
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OMIM |
604113
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CCDS |
CCDS44666
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HPRD |
04984
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IMGT |
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EMBL |
AB019504
AF110798
AF110799
AF110800
AF110801
AF122906
AF215907
AK098255
AP002490
BC044215
CH471076
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GenPept |
AAD17187
AAD17188
AAD17189
AAD17190
AAD17191
AAD17192
AAD41051
AAF31697
AAH44215
BAA76374
BAG53602
EAW74813
EAW74816
EAW74818
EAW74819
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