Homo sapiens Gene: IL18BP
Summary
InnateDB Gene IDBG-62960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL18BP
Gene Name interleukin 18 binding protein
Synonyms IL18BPa;
Species Homo sapiens
Ensembl Gene ENSG00000137496
Encoded Proteins
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
interleukin 18 binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn\'s disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:71998541-72005715
Strand Forward strand
Band q13.4
Transcripts
ENST00000343898 ENSP00000343309
ENST00000260049 ENSP00000260049
ENST00000337131 ENSP00000338723
ENST00000393707 ENSP00000377310
ENST00000393705 ENSP00000377308
ENST00000393703 ENSP00000377306
ENST00000404792 ENSP00000384212
ENST00000414358
ENST00000497194 ENSP00000434717
ENST00000525932
ENST00000531777
ENST00000531053 ENSP00000434835
ENST00000534583 ENSP00000434376
ENST00000620017 ENSP00000480621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 3 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042007 interleukin-18 binding
GO:0048019 receptor antagonist activity
Biological Process
GO:0032496 response to lipopolysaccharide
GO:0042088 T-helper 1 type immune response
GO:0070301 cellular response to hydrogen peroxide
GO:0071356 cellular response to tumor necrosis factor
GO:1900116 extracellular negative regulation of signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O95998
TrEMBL A0A024R5M7
UniProt Splice Variant
Entrez Gene 10068
UniGene Hs.591967
RefSeq NM_001145055 NM_001039659 NM_001039660 NM_001145057 NM_005699 NM_173042 NM_173044 XM_006718404
HUGO HGNC:5987
OMIM 604113
CCDS CCDS44666 CCDS8206
HPRD 04984
IMGT
EMBL AB019504 AF110798 AF110799 AF110800 AF110801 AF122906 AF215907 AK098255 AP002490 BC044215 CH471076
GenPept AAD17187 AAD17188 AAD17189 AAD17190 AAD17191 AAD17192 AAD41051 AAF31697 AAH44215 BAA76374 BAG53602 EAW74813 EAW74816 EAW74818 EAW74819
RNA Seq Atlas 10068