InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRF2

Summary

InnateDB Protein

IDBP-243306.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF2

Protein Name

interferon regulatory factor 2

Synonyms

IRF-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000377218

InnateDB Gene

IDBG-46310 (IRF2)

Protein Structure

UniProt Annotation

Function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269PubMed:12738767, ECO:0000269PubMed:15226432, ECO:0000269PubMed:18514056, ECO:0000269PubMed:9540062}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed throughout the epithelium of the colon. Also expressed in lamina propria. {ECO:0000269PubMed:15226432}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	46 [view]
Protein-DNA	43 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway