InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHF3

Summary

InnateDB Protein

IDBP-243714.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHF3

Protein Name

PHD finger protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377048

InnateDB Gene

IDBG-91739 (PHF3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas. {ECO:0000269PubMed:11856869}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR003618 Transcription elongation factor S-II, central domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR012921 Spen paralogue and orthologue SPOC, C-terminal
IPR017890 Transcription elongation factor S-IIM
IPR019787 Zinc finger, PHD-finger

PFAM

PF07500
PF07744
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00510

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92576