InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LGMN

Summary

InnateDB Protein

IDBP-244009.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGMN

Protein Name

legumain

Synonyms

AEP; LGMN1; PRSC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000376911

InnateDB Gene

IDBG-17093 (LGMN)

Protein Structure

UniProt Annotation

Function

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269PubMed:23776206}.

Subcellular Localization

Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Particularly abundant in kidney, heart and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008233	peptidase activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0003014	renal system process
GO:0006508	proteolysis
GO:0008202	steroid metabolic process
GO:0010447	response to acidity
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032801	receptor catabolic process
GO:0040015	negative regulation of multicellular organism growth
GO:0042359	vitamin D metabolic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:1901185	negative regulation of ERBB signaling pathway