InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MED21

Summary

InnateDB Protein

IDBP-24404.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED21

Protein Name

mediator complex subunit 21

Synonyms

hSrb7; SRB7; SURB7;

Species

Homo sapiens

Ensembl Protein

ENSP00000282892

InnateDB Gene

IDBG-24402 (MED21)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269PubMed:15249124, ECO:0000269PubMed:9660976}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	82 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0001824	blastocyst development
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0019827	stem cell maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter