Version 5.4
Homo sapiens Gene: MED21
Summary
InnateDB Gene IDBG-24402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED21
Gene Name mediator complex subunit 21
Synonyms hSrb7; SRB7; SURB7
Species Homo sapiens
Ensembl Gene ENSG00000152944
Encoded Proteins
IDBP-24404
mediator complex subunit 21
IDBP-587106
mediator complex subunit 21
IDBP-591422
mediator complex subunit 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:27022546-27066343
Strand Forward strand
Band p11.23
Transcripts
ENST00000282892 ENSP00000282892
ENST00000546323 ENSP00000442126
ENST00000536503
ENST00000536711 ENSP00000444297
ENST00000538186
ENST00000544998
ENST00000621885
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 82 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0001824 blastocyst development
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0019827 stem cell maintenance
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030291
View Gene Order
ENSBTAG00000005082
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.286145 Hs.712754 Hs.737553
RefSeq NM_001271811 NM_004264
HUGO
OMIM
CCDS CCDS8711
HPRD 09156
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca