Homo sapiens Gene: MED21
Summary
InnateDB Gene IDBG-24402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED21
Gene Name mediator complex subunit 21
Synonyms hSrb7; SRB7; SURB7;
Species Homo sapiens
Ensembl Gene ENSG00000152944
Encoded Proteins
mediator complex subunit 21
mediator complex subunit 21
mediator complex subunit 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:27022546-27066343
Strand Forward strand
Band p11.23
Transcripts
ENST00000282892 ENSP00000282892
ENST00000546323 ENSP00000442126
ENST00000536503
ENST00000536711 ENSP00000444297
ENST00000538186
ENST00000544998
ENST00000621885
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 82 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0001824 blastocyst development
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0019827 stem cell maintenance
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.286145 Hs.712754 Hs.737553
RefSeq NM_001271811 NM_004264
HUGO
OMIM
CCDS CCDS8711
HPRD 09156
IMGT
EMBL
GenPept
RNA Seq Atlas