InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NME1

Summary

InnateDB Protein

IDBP-244095.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME1

Protein Name

non-metastatic cells 1, protein (NM23A) expressed in

Synonyms

AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1;

Species

Homo sapiens

Ensembl Protein

ENSP00000376892

InnateDB Gene

IDBG-409263 (NME1)

Protein Structure

UniProt Annotation

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269PubMed:12628186, ECO:0000269PubMed:16818237, ECO:0000269PubMed:8810265}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16442775}. Nucleus {ECO:0000269PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. {ECO:0000269PubMed:10512675, ECO:0000269PubMed:12601555, ECO:0000269PubMed:16442775}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	63 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004536	deoxyribonuclease activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0042802	identical protein binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006308	DNA catabolic process
GO:0006897	endocytosis
GO:0008285	negative regulation of cell proliferation
GO:0015949	nucleobase-containing small molecule interconversion
GO:0042981	regulation of apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0044281	small molecule metabolic process
GO:0050679	positive regulation of epithelial cell proliferation
GO:0055086	nucleobase-containing small molecule metabolic process