InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NME1

Summary

InnateDB Gene

IDBG-409263.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

NME/NM23 nucleoside diphosphate kinase 1

Synonyms

AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1;

Species

Homo sapiens

Ensembl Gene

ENSG00000239672

Encoded Proteins

non-metastatic cells 1, protein (NM23A) expressed in

non-metastatic cells 1, protein (NM23A) expressed in

non-metastatic cells 1, protein (NM23A) expressed in

non-metastatic cells 1, protein (NM23A) expressed in

non-metastatic cells 1, protein (NM23A) expressed in

non-metastatic cells 1, protein (NM23A) expressed in

non-metastatic cells 1, protein (NM23A) expressed in

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of \'A\' (encoded by this gene) and \'B\' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:51153536-51162428

Strand

Forward strand

Band

q21.33

Transcripts

ENST00000336097	ENSP00000337060
ENST00000013034	ENSP00000013034
ENST00000393196	ENSP00000376892
ENST00000456492	ENSP00000387682
ENST00000487481
ENST00000480143	ENSP00000429318
ENST00000512768
ENST00000511355	ENSP00000428553
ENST00000475573	ENSP00000435498
ENST00000465188

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	63 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004536	deoxyribonuclease activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0042802	identical protein binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006308	DNA catabolic process
GO:0006897	endocytosis
GO:0008285	negative regulation of cell proliferation
GO:0015949	nucleobase-containing small molecule interconversion
GO:0042981	regulation of apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0044281	small molecule metabolic process
GO:0050679	positive regulation of epithelial cell proliferation
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000037601

View Gene Order

RBBH

Low

Tentative data, uncurated. RBBH derived.

Pathways

NETPATH

TGF_beta_Receptor pathway

REACTOME

Synthesis and interconversion of nucleotide di- and triphosphates pathway

Metabolism of nucleotides pathway

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

hsa00240

Pyrimidine metabolism pathway

INOH

Folate metabolism pathway

Purine nucleotides nucleosides metabolism pathway

Pyrimidine nucleotides nucleosides metabolism pathway

PID BIOCARTA

Endocytotic role of ndk phosphins and dynamin [Biocarta view]

Granzyme a mediated apoptosis pathway [Biocarta view]

PID NCI

ecadherin_nascentaj_pathway

E-cadherin signaling in the nascent adherens junction

myc_activpathway

Validated targets of C-MYC transcriptional activation

cdc42_reg_pathway

Regulation of CDC42 activity

arf6downstreampathway

Arf6 downstream pathway

arf6_traffickingpathway

Arf6 trafficking events

ajdiss_2pathway

Posttranslational regulation of adherens junction stability and dissassembly

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000269 NM_198175

HUGO

OMIM

CCDS

CCDS11578 CCDS11579

HPRD

01131

IMGT

EMBL

GenPept

RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca