Version 5.4
Homo sapiens Gene: NME1
Summary
InnateDB Gene IDBG-409263.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NME1
Gene Name NME/NM23 nucleoside diphosphate kinase 1
Synonyms AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1
Species Homo sapiens
Ensembl Gene ENSG00000239672
Encoded Proteins
IDBP-59614
non-metastatic cells 1, protein (NM23A) expressed in
IDBP-59616
non-metastatic cells 1, protein (NM23A) expressed in
IDBP-244095
non-metastatic cells 1, protein (NM23A) expressed in
IDBP-381897
non-metastatic cells 1, protein (NM23A) expressed in
IDBP-485172
non-metastatic cells 1, protein (NM23A) expressed in
IDBP-477315
non-metastatic cells 1, protein (NM23A) expressed in
IDBP-597592
non-metastatic cells 1, protein (NM23A) expressed in
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of \'A\' (encoded by this gene) and \'B\' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:51153536-51162428
Strand Forward strand
Band q21.33
Transcripts
ENST00000336097 ENSP00000337060
ENST00000013034 ENSP00000013034
ENST00000393196 ENSP00000376892
ENST00000456492 ENSP00000387682
ENST00000487481
ENST00000480143 ENSP00000429318
ENST00000512768
ENST00000511355 ENSP00000428553
ENST00000475573 ENSP00000435498
ENST00000465188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 63 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004536 deoxyribonuclease activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0042802 identical protein binding
GO:0043024 ribosomal small subunit binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006308 DNA catabolic process
GO:0006897 endocytosis
GO:0008285 negative regulation of cell proliferation
GO:0015949 nucleobase-containing small molecule interconversion
GO:0042981 regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0044281 small molecule metabolic process
GO:0050679 positive regulation of epithelial cell proliferation
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000037601
View Gene Order
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_21330
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Folate metabolism pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
myc_activpathway
Validated targets of C-MYC transcriptional activation
cdc42_reg_pathway
Regulation of CDC42 activity
arf6downstreampathway
Arf6 downstream pathway
arf6_traffickingpathway
Arf6 trafficking events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt P15531
TrEMBL C9K028 E7ERL0
UniProt Splice Variant
Entrez Gene 4830
UniGene
RefSeq NM_000269 NM_198175
HUGO HGNC:7849
OMIM 156490
CCDS CCDS11578 CCDS11579
HPRD 01131
IMGT
EMBL AC005839 AF487339 AK291105 BC000293 BC018994 CH471109 CR542104 CR542115 X17620 X73066 X75598
GenPept AAH00293 AAH18994 AAO85436 BAF83794 CAA35621 CAA51527 CAA53270 CAG46901 CAG46912 EAW94568
RNA Seq Atlas 4830

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca