InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STEAP3

Summary

InnateDB Protein

IDBP-244274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STEAP3

Protein Name

STEAP family member 3, metalloreductase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376822

InnateDB Gene

IDBG-67901 (STEAP3)

Protein Structure

UniProt Annotation

Function

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269PubMed:15319436, ECO:0000269PubMed:16651434}.

Subcellular Localization

Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

Disease Associations

Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. {ECO:0000269PubMed:22031863}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. {ECO:0000269PubMed:12606722, ECO:0000269PubMed:15885357, ECO:0000269PubMed:16227996}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000293	ferric-chelate reductase activity
GO:0005515	protein binding
GO:0008823	cupric reductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0009306	protein secretion
GO:0015677	copper ion import
GO:0033572	transferrin transport
GO:0043065	positive regulation of apoptotic process
GO:0055085	transmembrane transport
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1990182	exosomal secretion