InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STEAP3

Summary

InnateDB Gene

IDBG-67901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STEAP3

Gene Name

STEAP family member 3, metalloreductase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115107

Encoded Proteins

IDBP-244274

STEAP family member 3, metalloreductase

IDBP-244278

STEAP family member 3, metalloreductase

IDBP-244280

STEAP family member 3, metalloreductase

IDBP-294558

STEAP family member 3, metalloreductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:119223831-119265652

Strand

Forward strand

Band

q14.2

Transcripts

ENST00000393110	ENSP00000376822
ENST00000393107	ENSP00000376819
ENST00000393106	ENSP00000376818
ENST00000409811	ENSP00000386510

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000293	ferric-chelate reductase activity
GO:0005515	protein binding
GO:0008823	cupric reductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0009306	protein secretion
GO:0015677	copper ion import
GO:0033572	transferrin transport
GO:0043065	positive regulation of apoptotic process
GO:0055085	transmembrane transport
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1990182	exosomal secretion

Cellular Component

GO:0005768	endosome
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026389

View Gene Order

ENSBTAG00000007111

Not yet available

Pathways

NETPATH

REACTOME

REACT_25283

Transferrin endocytosis and recycling pathway

REACT_25060

Iron uptake and transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

Q658P3

TrEMBL

A0A024RAD7

UniProt Splice Variant

Entrez Gene

55240

UniGene

Hs.647822

RefSeq

NM_182915 NM_001008410 NM_018234 XM_006712613 XM_006712614 XM_006712615

HUGO

HGNC:24592

OMIM

609671

CCDS

CCDS42738 CCDS2125

HPRD

10285

IMGT

EMBL

AC016673 AC016736 AF238864 AF262322 AF423424 AK001691 AK291608 AL833624 AY029585 AY082673 AY214461 BC042150 BC095421 BX538047 CH471103

GenPept

AAH42150 AAH95421 AAK50538 AAL78206 AAM08128 AAM45136 AAO38238 AAQ04065 AAX88963 AAY14872 BAA91839 BAF84297 CAD97986 CAH56204 EAW95209 EAW95210 EAW95212

RNA Seq Atlas

55240