InnateDB Protein
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IDBP-244278.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STEAP3
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Protein Name
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STEAP family member 3, metalloreductase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376819
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InnateDB Gene
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IDBG-67901 (STEAP3)
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Protein Structure
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Function |
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269PubMed:15319436, ECO:0000269PubMed:16651434}.
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Subcellular Localization |
Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
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Disease Associations |
Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. {ECO:0000269PubMed:22031863}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. {ECO:0000269PubMed:12606722, ECO:0000269PubMed:15885357, ECO:0000269PubMed:16227996}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013130
Ferric reductase transmembrane component-like domain
IPR028939
Pyrroline-5-carboxylate reductase, catalytic, N-terminal
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PFAM |
PF01794
PF03807
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q658P3
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PhosphoSite |
PhosphoSite-Q658P3
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TrEMBL |
A0A024RAD7
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UniProt Splice Variant |
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Entrez Gene |
55240
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UniGene |
Hs.647822
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RefSeq |
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HUGO |
HGNC:24592
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OMIM |
609671
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CCDS |
CCDS2125
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HPRD |
10285
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IMGT |
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EMBL |
AC016673
AC016736
AF238864
AF262322
AF423424
AK001691
AK291608
AL833624
AY029585
AY082673
AY214461
BC042150
BC095421
BX538047
CH471103
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GenPept |
AAH42150
AAH95421
AAK50538
AAL78206
AAM08128
AAM45136
AAO38238
AAQ04065
AAX88963
AAY14872
BAA91839
BAF84297
CAD97986
CAH56204
EAW95209
EAW95210
EAW95212
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