InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA3E

Summary

InnateDB Protein

IDBP-24534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA3E

Protein Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Synonyms

coll-5; M-SEMAH; M-SemaK; SEMAH;

Species

Homo sapiens

Ensembl Protein

ENSP00000303212

InnateDB Gene

IDBG-24532 (SEMA3E)

Protein Structure

UniProt Annotation

Function

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0008360	regulation of cell shape
GO:0016525	negative regulation of angiogenesis
GO:0050808	synapse organization
GO:0071526	semaphorin-plexin signaling pathway
GO:2000249	regulation of actin cytoskeleton reorganization