Homo sapiens Gene: SEMA3E
Summary
InnateDB Gene IDBG-24532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA3E
Gene Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms coll-5; M-SEMAH; M-SemaK; SEMAH;
Species Homo sapiens
Ensembl Gene ENSG00000170381
Encoded Proteins
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:83363906-83649010
Strand Reverse strand
Band q21.11
Transcripts
ENST00000307792 ENSP00000303212
ENST00000427262 ENSP00000405052
ENST00000442159 ENSP00000412867
ENST00000453333 ENSP00000415184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0016525 negative regulation of angiogenesis
GO:0050808 synapse organization
GO:0071526 semaphorin-plexin signaling pathway
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
Axon guidance pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Plexin-D1 Signaling
Cross-References
SwissProt O15041
TrEMBL C9JVH5 F8WCZ5
UniProt Splice Variant
Entrez Gene 9723
UniGene Hs.528721 Hs.630822 Hs.642416
RefSeq NM_012431 XM_006716187 NM_001178129
HUGO HGNC:10727
OMIM 608166
CCDS CCDS34674 CCDS55121
HPRD 11545
IMGT
EMBL AB002329 AC004954 AC006204 AC079799 AC079987 AK303925
GenPept AAC69513 AAS07487 AAS07488 BAA20789 BAG64853
RNA Seq Atlas 9723