InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEMA3E

Summary

InnateDB Gene

IDBG-24532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA3E

Gene Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Synonyms

coll-5; M-SEMAH; M-SemaK; SEMAH

Species

Homo sapiens

Ensembl Gene

ENSG00000170381

Encoded Proteins

IDBP-24534

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

IDBP-380560

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

IDBP-380561

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

IDBP-380562

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:83363906-83649010

Strand

Reverse strand

Band

q21.11

Transcripts

ENST00000307792	ENSP00000303212
ENST00000427262	ENSP00000405052
ENST00000442159	ENSP00000412867
ENST00000453333	ENSP00000415184

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0008360	regulation of cell shape
GO:0016525	negative regulation of angiogenesis
GO:0050808	synapse organization
GO:0071526	semaphorin-plexin signaling pathway
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000063531

View Gene Order

ENSBTAG00000014920

Not yet available

Pathways

NETPATH

REACTOME

REACT_19200

Other semaphorin interactions pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

plexind1_pathway

Plexin-D1 Signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.528721 Hs.630822 Hs.642416

RefSeq

NM_001178129 NM_012431 XM_006716187

HUGO

OMIM

CCDS

CCDS34674 CCDS55121

HPRD

11545

IMGT

EMBL

GenPept

RNA Seq Atlas