InnateDB Protein
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IDBP-245452.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP5G3
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Protein Name
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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
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Synonyms
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P3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376324
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InnateDB Gene
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IDBG-75631 (ATP5G3)
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Protein Structure
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Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
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Subcellular Localization |
Mitochondrion membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0015986
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ATP synthesis coupled proton transport
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GO:0015991
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ATP hydrolysis coupled proton transport
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Cellular Component |
GO:0005753
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mitochondrial proton-transporting ATP synthase complex
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GO:0016021
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integral component of membrane
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GO:0033177
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proton-transporting two-sector ATPase complex, proton-transporting domain
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GO:0045263
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proton-transporting ATP synthase complex, coupling factor F(o)
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PDB ID |
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InterPro |
IPR000454
ATPase, F0 complex, subunit C
IPR002379
V-ATPase proteolipid subunit C-like domain
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PFAM |
PF00137
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PRINTS |
PR00124
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P48201
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
518
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UniGene |
Hs.708491
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RefSeq |
NP_001177258
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HUGO |
HGNC:843
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OMIM |
602736
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CCDS |
CCDS2263
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HPRD |
04112
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IMGT |
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EMBL |
AC096649
AK311999
BC106881
CH471058
U09813
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GenPept |
AAA78807
AAI06882
AAX88970
BAG34937
EAX11106
EAX11107
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