InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: URI1

Summary

InnateDB Protein

IDBP-245998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

URI1

Protein Name

chromosome 19 open reading frame 2

Synonyms

C19orf2; NNX3; PPP1R19; RMP; URI;

Species

Homo sapiens

Ensembl Protein

ENSP00000376097

InnateDB Gene

IDBG-41955 (URI1)

Protein Structure

UniProt Annotation

Function

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Subcellular Localization

Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. {ECO:0000269PubMed:21397856, ECO:0000269PubMed:21730289, ECO:0000269PubMed:9819440, ECO:0000269PubMed:9878255}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003682	chromatin binding
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001558	regulation of cell growth
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006457	protein folding
GO:0009615	response to virus
GO:0010923	negative regulation of phosphatase activity
GO:0071363	cellular response to growth factor stimulus
GO:0071383	cellular response to steroid hormone stimulus
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016272	prefoldin complex
GO:0030425	dendrite