InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: URI1

Summary

InnateDB Gene

IDBG-41955.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

URI1

Gene Name

URI1, prefoldin-like chaperone

Synonyms

C19orf2; NNX3; PPP1R19; RMP; URI

Species

Homo sapiens

Ensembl Gene

ENSG00000105176

Encoded Proteins

IDBP-41957

chromosome 19 open reading frame 2

IDBP-245998

chromosome 19 open reading frame 2

IDBP-763150

IDBP-765768

IDBP-762544

IDBP-764240

IDBP-760808

IDBP-763372

IDBP-763646

IDBP-761865

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:29923644-30016608

Strand

Forward strand

Band

q12

Transcripts

ENST00000360605	ENSP00000353817
ENST00000392271	ENSP00000376097
ENST00000574233	ENSP00000458480
ENST00000570704
ENST00000585655	ENSP00000468048
ENST00000574176
ENST00000570564	ENSP00000459966
ENST00000574110	ENSP00000461003
ENST00000575242	ENSP00000459450
ENST00000576442	ENSP00000461895
ENST00000574766
ENST00000573052	ENSP00000458161
ENST00000574666	ENSP00000458533

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003682	chromatin binding
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001558	regulation of cell growth
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006457	protein folding
GO:0009615	response to virus
GO:0010923	negative regulation of phosphatase activity
GO:0071363	cellular response to growth factor stimulus
GO:0071383	cellular response to steroid hormone stimulus
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016272	prefoldin complex
GO:0030425	dendrite

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030421

View Gene Order

ENSBTAG00000007559

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.466391 Hs.607593 Hs.669840

RefSeq

NM_001252641 NM_003796 XM_005259362

HUGO

OMIM

CCDS

CCDS12420 CCDS58658

HPRD

11943

IMGT

EMBL

GenPept

RNA Seq Atlas