Homo sapiens Gene: URI1
Summary
InnateDB Gene IDBG-41955.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol URI1
Gene Name URI1, prefoldin-like chaperone
Synonyms C19orf2; NNX3; PPP1R19; RMP; URI;
Species Homo sapiens
Ensembl Gene ENSG00000105176
Encoded Proteins
chromosome 19 open reading frame 2
chromosome 19 open reading frame 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:29923644-30016608
Strand Forward strand
Band q12
Transcripts
ENST00000360605 ENSP00000353817
ENST00000392271 ENSP00000376097
ENST00000574233 ENSP00000458480
ENST00000570704
ENST00000585655 ENSP00000468048
ENST00000574176
ENST00000570564 ENSP00000459966
ENST00000574110 ENSP00000461003
ENST00000575242 ENSP00000459450
ENST00000576442 ENSP00000461895
ENST00000574766
ENST00000573052 ENSP00000458161
ENST00000574666 ENSP00000458533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001558 regulation of cell growth
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006457 protein folding
GO:0009615 response to virus
GO:0010923 negative regulation of phosphatase activity
GO:0071363 cellular response to growth factor stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016272 prefoldin complex
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL I3L104 I3L2V7
UniProt Splice Variant
Entrez Gene 8725
UniGene Hs.466391 Hs.607593 Hs.669840
RefSeq NM_001252641 NM_003796 XM_005259362
HUGO HGNC:13236
OMIM 603494
CCDS CCDS12420 CCDS58658
HPRD 11943
IMGT
EMBL AC008507
GenPept
RNA Seq Atlas 8725