InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDHC

Summary

InnateDB Protein

IDBP-246206.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDHC

Protein Name

succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa

Synonyms

CYB560; CYBL; PGL3; QPS1; SDH3;

Species

Homo sapiens

Ensembl Protein

ENSP00000376009

InnateDB Gene

IDBG-104271 (SDHC)

Protein Structure

UniProt Annotation

Function

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Paragangliomas 3 (PGL3) [MIM:605373]: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear. {ECO:0000269PubMed:11062460}. Note=The disease is caused by mutations affecting the gene represented in this entry.Paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]: Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. {ECO:0000269PubMed:17804857}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000104	succinate dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0009060	aerobic respiration
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II
GO:0016021	integral component of membrane
GO:0045273	respiratory chain complex II
GO:0045281	succinate dehydrogenase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit
IPR014314 Succinate dehydrogenase, cytochrome b556 subunit
IPR014361 Succinate dehydrogenase, cytochrome b560 subunit

PFAM

PF01127

PRINTS

PIRSF

PIRSF000178

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99643