Homo sapiens Gene: SDHC
Summary
InnateDB Gene IDBG-104271.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SDHC
Gene Name succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Synonyms CYB560; CYBL; PGL3; QPS1; SDH3;
Species Homo sapiens
Ensembl Gene ENSG00000143252
Encoded Proteins
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161314257-161375340
Strand Forward strand
Band q23.3
Transcripts
ENST00000367975 ENSP00000356953
ENST00000342751 ENSP00000356952
ENST00000392169 ENSP00000376009
ENST00000432287 ENSP00000390558
ENST00000515731
ENST00000513009 ENSP00000423260
ENST00000504963 ENSP00000423929
ENST00000470743 ENSP00000482902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000104 succinate dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005749 mitochondrial respiratory chain complex II
GO:0016021 integral component of membrane
GO:0045273 respiratory chain complex II
GO:0045281 succinate dehydrogenase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Citric acid cycle (TCA cycle) pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Citrate cycle (TCA cycle) pathway
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444472 Hs.632231 Hs.711955
RefSeq NM_001035511 NM_001035512 NM_001035513 NM_001278172 NM_003001
HUGO
OMIM
CCDS CCDS1230 CCDS41431 CCDS41432 CCDS44263 CCDS60330
HPRD 03878
IMGT
EMBL
GenPept
RNA Seq Atlas