InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD247

Summary

InnateDB Protein

IDBP-246301.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD247

Protein Name

CD247 molecule

Synonyms

CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ;

Species

Homo sapiens

Ensembl Protein

ENSP00000375969

InnateDB Gene

IDBG-104547 (CD247)

Protein Structure

UniProt Annotation

Function

Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]: An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. {ECO:0000269PubMed:16672702}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0016032	viral process
GO:0031295	T cell costimulation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0050690	regulation of defense response to virus by virus
GO:0050776	regulation of immune response
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042101	T cell receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR003110 Phosphorylated immunoreceptor signalling ITAM
IPR021663 T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit

PFAM

PF02189
PF11628

PRINTS

PIRSF

SMART

SM00077

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20963